Publications
Kennedy PH, Alborzian Deh Sheikh A, Balakar M, Jones AC, Olive ME, Hegde M, Matias MI, Pierte N, Burt R, Levy J, Little T, Hogan PG, Liu DR, Doench JG, Newton AC, Gottschalk RA, de Boer C, Alacron S, Newby GA, Myers SA. Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput. Nature Methods. 2024 Apr 29. doi: 10.1038/s41592-024-02256-z. Online ahead of print. PMID: 3868478
Larange A, Takazawa I, Kakugawa K, Thiault N, Ngoi SM, Olive ME, Iwaya H, Seguin L, Vincente-Suarez I, Becart S, Verstichel G, Balancio A, Altman A, Chang JT, Taniuchi I, Lillemeier B, Kronenberg M, Myers SA‡, Cheroutre H‡. A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function. ‡co-corresponding author. Immunity. 2023 Aug 13;S1074-7613(23)00330-8. doi: 10.1016/j.immuni.2023.07.017.Online ahead of print
Li X, Yue X, Sepulveda H, Burt RA, Scott DA, Carr SA, Myers SA‡, Rao A‡. OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis. ‡co-corresponding author. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2218332120. doi: 10.1073/pnas.2218332120.
Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS, Mullally A. CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response. Leukemia 2022 Dec 6. doi: 10.1038/s41375-022-01781-0.
Palka C, Fishman CB, Bhattarai-Kline S, Myers SA, Shipman SL. Retron reverse transcriptase termination and phage defense are dependent on host RNase H1. Nucleic Acids Research 2022 Apr 8;50(6):3490-3504. doi: 10.1093/nar/gkac177
Myers SA & Gottschalk RA. Mechanisms encoding STAT functional diversity for context-specific inflammatory responses. Current Opinions in Immunology 2022 Feb;74:150-155. doi: 10.1016/j.coi.2022.01.011
Ludwig L, Lareau C, Bao E, Utsugiawa T, Myers SA, Veroon J, Ulirsch J, Muss C, Fiorini C, Vockley C, Munschauer M, Hunter A, Orgura H, Yamamoto T, Inada H, Nakagawa S, Ohzono S, Subramanian V, Chiarle R, Glader B, Carr SA, Aryee J, Regev A, McCavit TL, Kanno H, Sankaran VG. A Congenital Anemia Dissociates the Pleiotropic Functions of Master Transcription Factor GATA1. Blood 2022 Jan 14;blood.2021013753. doi: 10.1182/blood.2021013753.
Ghosh S, Raundhal M, Myers SA, Carr SA, Chen X, Petsko GA, Glimcher LC. Identification of RIOK2 as a master regulator of human blood cell development. Nature Immunology 2022 23, 109–121. https://doi.org/10.1038/s41590-021-01079-w
Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA. Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides. Molecular and Cellular Proteomics 2021 Oct 20;20:100167. PMID: 34678516, PMCID: PMC8605273. doi: 10.1016/j.mcpro.2021.100167; bioRxiv 2021 doi:10.1101/2021.05.28.446228.
Qin, W, Myers SA, Carey DK, Carr SA, Ting AY. Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor that promotes stress recovery. Nature Communications 2021 Aug 17;12(1):4980. doi: 10.1038/s41467-021-25259-2.
Raundhal M, Ghosh S, Myers SA, Cuoco MS, Singer M, Carr SA, Waiker SS, Bonventre JV, Ritz J, Stone RM, Steensma D, Regev A, Glimcher LJ. Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Nature Immunology 2020 Dec 15(12):3971-3999. doi: 10.1038/s41596-020-0399-0. Epub 2020 Nov 2.PMID: 33139955.
Cho KF, Branon TC, Udeshi ND, Myers SA, Carr SA, Ting AY. Proximity labeling in mammalian cells with TurboID and split-TurboID. Nature Protocols 2020 Nov 2. doi: 10.1038/s41596-020-0399-0.
Han S, Hao B, Myers SA, Carr SA, He C, Ting AY. RNA-protein interaction mapping via MS2 or Cas13-based APEX targeting. Proceedings of the National Academy of Sciences, 2020 Sep 8;117(36):22068-22079. doi.org/10.1073/pnas.2006617117.
Hebert JD, Myers SA, Naba A, Abbruzzese G, Lamar J, Carr SA, Hynes RO. Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Cancer Research, 2020, Apr 1;80(7):1475-1485. doi:10.1158/0008-5472.CAN-19-2961.
Paskus JD, Tian Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD, Bemben MA, Herring BE, Roche KW. Synaptic Kalirin-7 and Trio interactomes reveal a GEF protein-dependent Neuroligin-1 mechanism of action. Cell Reports, 2019, Dec 3;29(10):2944-2952.e5. doi: 10.1016/j.celrep.2019.10.115
Papanastasiou M, Mullahoo J, DeRuff K, Bajrami B, Johnston SE, Peckner R, Carr SA, Myers SA, Jaffe JD. Papanastasiou M, Mullahoo J, DeRuff K, Bajrami B, Johnston SE, Peckner R, Carr SA, Myers SA, Jaffe JD. Chasing tails: Cathepsin-L for the analysis of histone tails by HX-MS. Molecular and Cellular Proteomics, 2019, Oct: 18(10): 2089-2098. doi: 10.1074/mcp.RA119.001325.
Rizk J, Kaplinsky J, Agerholm R, Kadekar D, Ivars F, Agace WW, Wong L, Szucs MJ, Myers SA, Carr SA, Waisman A, Bekiaris V. SMAC mimetics inhibit NIK-dependent CD4+ Th17 differentiation. Science Signaling, 2019, Aug 27;12(596). pii: eaaw3469. doi: 10.1126/scisignal.aaw3469.
Katrancha S, Shaw J, Zhao A, Myers SA, Cocco AR, Jeng A, Zhu M, Pittenger C, Greer C, Carr SA, Xiao X, Koleske A. Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Cell Reports, 2019, May 5 (26) 2805–2817, doi.org/10.1016/j.celrep.2019.02.022.
Myers SA‡, Rhoads A, Cocco AR, Peckner R, Haber A, Schweitzer LD, Krug K, Mani DR, Clauser KR, Rozenblatt-Rozen O, Hacohen N, Regev A, Carr SA‡. Streamlined protocol for deep proteomic profiling of FAC-sorted cells and its application to freshly isolated murine immune cells. Molecular and Cellular Proteomics, 2019, Feb 21 18 (5) 995-1009. doi: 10.1074/mcp.RA118.001259. ‡co-corresponding author. Highlighted in MCP’s Technological Innovations Virtual Issue 2020 Apr 1. https://doi.org/10.1074/mcp.E120.002042
Myers SA‡, Klaeger S, Satpathy S, Viner R, Choi J, Rogers J, Clauser KR, Udeshi ND, Carr SA‡. Evaluation of advanced precursor determination for tandem mass tag (TMT)-based quantitative proteomics across instrument platforms. Journal of Proteome Research, 2018, Oct 23. doi: 10.1021/acs.jproteome.8b00611. ‡co-corresponding author
Myers SA‡, Wright J, Peckner R, Kalish BT, Zhang F, Carr SA‡. Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling. Nature Methods, 2018, May 7.doi: 10.1038/s41592018-0007-1. ‡co-corresponding author. F1000 recommended article.
Peckner R, Myers SA, Jacome ASV, Egertson JD, Abelin JG, MacCoss MJ, Carr SA, Jaffe JD. Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics. Nature Methods, 2018, May 15(5):371-378. doi: 10.1038/nmeth.4643.
Udeshi ND, Pedram K, Svinkina T, Fereshetian S, Myers SA, Aygun O, Krug K, Clauser K, Ryan D, Ast T, Mootha VK, Ting AY, Carr SA. Antibodies to biotin enable large-scale detection of biotinylation sites on proteins. Nature Methods, 2017, Dec;14(12):1167-1170 doi: 10.1038/nmeth.4465.
Lewis BA, Burlingame AL, Myers SA. Human RNA Polymerase II promoter recruitment in vitro is regulated by OGT. Journal of Biological Chemistry, 2016, July 1;291(27):14056-61.
Myers SA*, Peddada S*, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B. SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells. eLife, 2016, 10.7554/eLife.10647.
Myers SA, Daou S, Affar el B, Burlingame AL. Electron transfer dissociation (ETD): the mass spectrometric breakthrough essential for O-GlcNAc protein site assignments- a study of the O-GlcNAcylated protein host cell factor C1. Proteomics, 2013, 13(6):982-91
Le D, Cortesi A, Myers SA, Burlingame AL, Fujimori D. Site- and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding. Journal American Chemical Society, 2013, 135(8):2879-82.
Myers SA, Panning B, Burlingame AL. Polycomb repressive complex 2 is necessary for the normal site specific O-GlcNAc distribution in mouse embryonic stem cells. Proceedings of the National Academy of Sciences, 2011, 23(108):9490-95.
Tang YJ, Shui W, Myers SA, Rodriguez S, Bertozzi CR, Keasling JD. Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis. Biotechnology Letters, 2009, (8):1233-40.
Tang YJ, Sapra, R, Joyner D, Hazen TC, Myers SA, Reichmuth D, Blanch H, Keasling JD. Analysis of metabolic pathways and fluxes in a newly discovered thermophilic and ethanol-tolerant Geobacillus strain. Biotechnology and Bioengineering, 2009, 102(5):1377-86
Tang YJ, Martin HG, Myers SA, Rodriguez S, Baidoo EE, Keasling JD. Advances in analysis of microbial metabolic fluxes via (13)C isotopic labeling. Mass Spectrometry Reviews, 2009, 28 (2):362-75.
Steen EJ, Chan R, Prasad N, Myers SA, Petzold CJ, Redding A, Ouellet M, Keasling JD. Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microbial Cell Factories, 2008, Dec 3; 7:36 doi: 10.1186/1475-2859-7-36.
Yu SB, Sanchez RG, Papich ZD, Whisenant TC, Rodriguez CM, Ghassemian M, Koberstein JN, Steward ML, Myers SA, Pekkurnaz G. Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity. Developmental Cell. 2025 Aug 19;59(16):2143-2157.e9. doi: 10.1016/j.devcel.2024.05.008.Epub 2024 Jun 5. PMID: 38843836
Dong Z, Sepulveda H, Vazquez LJA, Binder M, Chou WC, Tien HF, Faulkner GJ, Patnak M, Myers SA, Rao A. A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia. PNAS. 2025 Jan 7;122(1):e2413302121. doi: 10.1073/pnas.2413302121.Epub 2025 Jan 3. PMID: 39752521